Psoriasis is a long-term inflammatory skin condition linked to poor skin barrier function and excessive keratinocyte proliferation. Conventional treatments often show systemic adverse effects, low bioavailability, and poor skin penetration. Transdermal medication delivery systems based on nanotechnology have become viable alternatives to manage psoriasis. Drug penetration, stability, controlled release, and targeted treatment to psoriatic lesions are boosted by nanocarriers like liposomes, ethosomes, transfersomes, solid lipid nanoparticles, nanostructured lipid carriers, and polymeric nanoparticles. These advances enhance patient compliance, decrease toxicity, and increase therapeutic efficacy. The latest advancements, therapeutic advantages, difficulties, and potential applications of novel nano technological platforms in transdermal anti-psoriatic drug administration are presented in this chapter.