Arthritis is a common condition that majorly affects joint function and the quality of life for millions of people globally. Among its various forms, rheumatoid arthritis is particularly notable due to its complex pathophysiology and chronic inflammatory nature which is presenting significant challenges for effective treatment. Traditional therapies often fail to provide long-term relief or prevent disease progression, highlighting the need for innovative solutions. In these years, Hydrogels have approached as a promising strategy for managing arthritis treatment. Their different properties such as high water content, excellent mechanical integrity and the ability to deliver drugs in a sustained manner that make them well-suited for meeting the complex requirements of arthritis treatment. NSAIDs are commonly used as first-line treatments, but long-term use is linked to cardiovascular, gastrointestinal and renal issues. Drug delivery systems like nanoparticles, liposomes, and hydrogels have developed to improve NSAID efficacy and reduce toxicity. Hydrogels classified as natural, synthetic or hybrid that offer sustained and controlled drug release and can respond to external stimuli like temperature, pH or enzymes ensuring targeted delivery. Advancements in these technologies show enhanced pain relief management and reduced side effects for arthritis patients. Hydrogels, with their versatile characteristics and diverse applications are making an impact on industries such as medicine, environmental science, energy and agriculture. Their potential to revolutionize medical treatment, address sustainability issues and improve everyday life makes them as a critical material for future innovations.