The birth of a low-birth-weight (LBW) infant and the admission that often follows to a neonatal intensive or special care unit is one of the most psychologically demanding events a mother can face. Alongside the physical tasks of thermal protection, feeding, hygiene, and Kangaroo Mother Care (KMC) examined elsewhere in this literature, mothers must also manage fear, uncertainty, guilt, and disrupted expectations of early motherhood. Evidence from India and other low- and middle-income settings indicates that a substantial proportion of these mothers experience clinically significant stress, anxiety, or depressive symptoms, both during neonatal unit admission and after discharge, yet psychological adjustment remains comparatively under-addressed in routine nursing care. This chapter uses Lazarus and Folkman's Transactional Model of Stress and Coping to examine how mothers appraise the demands of caring for an LBW infant, the resources they draw upon, and the problem-focused and emotion-focused coping strategies they use to manage this appraisal. It reviews the prevalence and determinants of maternal stress, tools available for its assessment, and the evidence base for nursing and psychosocial interventions — including KMC, mindfulness-based approaches, family-integrated care, and structured peer support — that can buffer stress and strengthen coping. The chapter situates this evidence within a planned programme of nurse-led, home-based support for mothers of LBW infants in Kollam District, Kerala, consistent with the broader programme of work presented in this thesis. The chapter argues that psychological adjustment and physical caregiving competence are inseparable: a mother who is overwhelmed by appraisal of threat and lacking coping resources is less likely to sustain safe, consistent home care, regardless of how much factual knowledge she has been given. Nurses are positioned as central to interrupting this pathway, through early screening, honest information-sharing, active involvement of mothers in care, emotional and social support, monitoring across the transition from hospital to home, and timely referral when distress is severe. The chapter closes with an integrated conceptual framework, implications for nursing practice, education, and policy, and a future research agenda centred on longitudinal, culturally grounded, and intervention-focused study of maternal coping.